News

We will have the pleasure of attending a virtual B2B event, „Baltic Photonics 2021 MedLife“, on the 16th of September!

This online conference focuses on medical life sciences intending to promote Baltic photonics and laser technologies, life science and medical research and innovations.

 

We will present our SERS-based solutions and the potential of combining them with Artificial Intelligence, which might be a brand new way for medical diagnosis of pathogens and life sciences research.

 

Event page: https://toolas.eu/baltic-photonics-2021-medlife/

Registration is free of charge: https://forms.gle/pm2xhpnssRK4Z6Xp7

(all registered participants will receive a link to translation platform, where they can as questions to the speakers in the chat)

 

Join us on September 16, 2021 🙂

Keywords: SERS-based solutions, Raman, Baltic Photonics, Toolas, medical life sciences, photonics, laser technologies, medicine, research and development, innovations, combining with Artificial Intelligence, diagnosis of pathogens, biology, pharmaceutical, biomedicine
Concentration-dependent SERS profile of olanzapine on silver and silver-gold metallic substrates.

Jamelah S. Al-Otaibi, Paweł Albrycht, Y. Sheena Mary, Y. Shyma Mary & Monika Księżopolska-Gocalska

Using nanosized metal substrates, surface-enhanced Raman scattering (SERS) is a tool for improving the Raman signal of biomolecules. For detection, SERS has gained much popularity and an important role in determining chemical composition. In the present study, SERS spectra of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine (olanzapine) (MPTB) were investigated on silver and silver-gold metal substrates (SERSitive, Warsaw, Poland) at different concentrations. Also, different chemical and electronic properties are investigated using DFT calculations. The ring and other functional modes in SERS change in frequency values with variations in intensity for all concentrations. The molecule is oriented in a tilted manner with respect to Ag and Ag-Au.

Keywords: DFT, SERS, Benzodiazepine, Metal substrates, Ag, Ag-Au, SERS, Raman, photoscience in biology, experimental techniques, Raman spectroscopy, theoretical approaches, single molecules, synthesis methods, ultrafast photochemistry, photoscience at nanoscale, infrared spectroscopy, surface enhanced raman spectroscopy, press, sciene, big scale research,
Surface enhanced Raman scattering investigation of pioglitazone on silver and silver-gold metal substrates – Experimental analysis and theoretical modelling

Paweł Albrycht, Jamelah S. Al-Otaibi, Y. Sheena Mary, Y. Shyma Mary, Ravi Trivedi, Brahmananda Chakraborty

Surface enhanced Raman scattering (SERS) is a spectroscopic technique for trace analysis where the efficiency depends on the substrate. In the present work, concentration-dependent SERS of pioglitazone (EPMT) in silver and silver-gold substrates are reported. The presence and absence of different SERS peaks between the analyte spectra on silver and silver-gold substrates show that there is an orientation change of the analyte adsorbed depending on the surface-active metal. The density functional theory (DFT) method was used to verify the experimental findings obtained from normal Raman and SERS spectra. Theoretical modeling of EPMT and metal clusters are reported and enhancement factors are found from theoretical and experimental results. In the EPMT-Ag-Ag and EPMT-Ag-Au molecular systems, Frontier molecular orbital’s (FMO’s) results highlight charge transfers from Ag-Ag/Ag-Au clusters to the molecule. Furthermore, the SERS enhancement factor values show that EPMT is chemisorbed.

Keywords: Pioglitazone, SERS, Raman, photoscience in biology, experimental techniques, Raman spectroscopy, theoretical approaches, single molecules, synthesis methods, ultrafast photochemistry, photoscience at nanoscale, infrared spectroscopy, surface enhanced raman spectroscopy, press, sciene, big scale research,
SERSitive Awarded!!! at Polish Product of the Future competition held by PARP and NCBiR

We are so excited! Our ideas for developing SERSitive SERS substrates for biomedicine applications were appreciated by the PARP and NCBiR for the most innovative Polish products and technologies in the competition for the Polish Product of the Future!
We were honoured with two awards:

1) Distinction Award in the category “Modern Science Solutions”
2) Special Award of the Ministry of Education and Science

We are very thankful that we could participate in this prestigious competition and could share our #innovativesolutions 😊

More:
ScienceInPoland
Innovations
PARP catalogue (Polish version only)

Keywords: PARP, NCBiR, NCBR, PPP, Polish Product of the Future, Award, Competition, SERSitive winning, SERS, Raman, photoscience in biology, experimental techniques, Raman spectroscopy, theoretical approaches, single molecules, synthesis methods, ultrafast photochemistry, photoscience at nanoscale, infrared spectroscopy, surface enhanced raman spectroscopy, press, sciene, big scale research,
Formation of Citrazinic Acid Ions and Their Contribution to Optical and Magnetic Features of Carbon Nanodots: A Combined Experimental and Computational Approach

MOCCI F, OLLA C, CAPPAI A, CORPINO R, RICCI PC, CHIRIU D, SALIS M, CARBONARO CM.

The molecular model is one of the most appealing to explain the peculiar optical properties of Carbon nanodots (CNDs) and was proven to be successful for the bottom up synthesis, where a few molecules were recognized. Among the others, citrazinic acid is relevant for the synthesis of citric acid-based CNDs. Here we report a combined experimental and computational approach to discuss the formation of different protonated and deprotonated species of citrazinic acid and their contribution to vibrational and magnetic spectra. By computing the free energy formation in water solution, we selected the most favoured species and we retrieved their presence in the experimental surface enhanced Raman spectra. As well, the chemical shifts are discussed in terms of tautomers and rotamers of most favoured species. The expected formation of protonated and de-protonated citrazinic acid ions under extreme pH conditions was proven by evaluating specific interactions with H2SO4 and NaOH molecules. The reported results confirm that the presence of citrazinic acid and its ionic forms should be considered in the interpretation of the spectroscopic features of CNDs.

Keywords: SERS, citrazinic acid; Raman spectroscopy; NMR spectroscopy; carbon nanodots; DFT calculations
Insight into the Molecular Model in Carbon Dots through Experimental and Theoretical Analysis of Citrazinic Acid in Aqueous Solution

Antonio Cappai, Claudio Melis, Luigi Stagi, Pier C. Ricci, Francesca Mocci, and Carlo M. Carbonaro

The molecular emission model is the most accredited one to explain the emission properties of carbon dots (CDs) in a low-temperature bottom-up synthesis approach. In the case of citric acid and urea, the formation of a citrazinic acid (CZA) single monomer and oligomers is expected to affect the optical properties of the CDs. It is therefore mandatory to elucidate the possible role of weak bonding interactions in determining the UV absorption spectrum of some molecular aggregates of CZA. Although this carboxylic acid is largely exploited in the synthesis of luminescent CDs, a full understanding of its role in determining the final emission spectra of the produced CDs is still very far to be achieved. To this aim, by relying on purely first-principles density functional theory calculations combined with experimental optical characterization, we built and checked the stability of some molecular aggregates, which could possibly arise from the formation of oligomers of CZA, mainly dimers, trimers, and some selected tetramers. The computed vibrational fingerprint of the formation of aggregates is confirmed by surface-enhanced Raman spectroscopy. The comparison of experimental data with calculated UV absorption spectra showed a clear impact of the final morphology of the aggregates on the position of the main peaks in the UV spectra, with particular regard to the 340 nm peak associated with n-π* transition.

Keywords: SERS, Citrazinic Acid in Aqueous Solution, carbon dots
We would like to invite you for the online conference ‘smallChem’

17-18 Februbary 2021, International Online Conference- WE LOOK FORWARD TO MEETING YOU There!

 

The two-day Small Chem 2021 Online International Conference will present the most recent advances in fundamental research, technology developments and business opportunities in the Chemistry sector. More than 25 high profile talks from worldwide most influential academia & industry experts will present speeches in this international event on how chemistry latest advances will impact positively our daily life.
Small Chem 2021 will be a two-day online event that means to gather the key players of the Chemistry community and related sectors. This event is launched considering that all major scientific and technological in-person conferences are being cancelled or postponed worldwide until middle of 2021.

Keywords: SERS, Raman, photoscience in biology, experimental techniques, Raman spectroscopy, theoretical approaches, single molecules, synthesis methods, ultrafast photochemistry, photoscience at nanoscale, infrared spectroscopy, surface enhanced raman spectroscopy, press, sciene, big scale research,
30.11 – 01.12 2020, ONLINE on YouTube – WE LOOK FORWARD TO MEETING YOU THERE!

We would like to invite you and your community to an event like never before, where it is not your skills but your groundbreaking dreams that count!
Welcome to international competition for young scientists:

Dream Chemistry Award 2020

with the special event:
Perspectives on the chemistry publishing landscape.
Lecture delivered by Russell Johnson editor at Nature Chemistry

Dream Chemistry Award

Day 1
30th of November 2020, 06:00 p.m. – 10:00 p.m. CET
Opening ceremony
&
Lectures of the 5 Top Finalists of the DCA 2020
YouTube online stream of DCA 2020 – Day 1

Day 2
1st of December 2020, 06:00 p.m. – 09:00 p.m. CET
Lecture of the winner of the DCA 2020
&
Special event:
Perspectives on the chemistry publishing landscape
Lecture delivered by Russel Johnson editor at Nature Chemistry
YouTube online stream of DCA 2020 – Day 2

Keywords: Dream, Chemistry, Award, Dream Chemistry Award, 2020, Institute of Physical Chemistry PAS, Physical Chemistry, Organic Chemistry, Prize, Holyst, Hołyst, Institute of Organic Chemistry and Biochemistry of the CAS, Biochemistry, Jungwirth
The most beautiful city and the biggest conference on Raman Spectroscopy now at the same time in the same place: XXVII International Conference on Raman Spectroscopy

1-6 AUGUST 2021, ROME, ITALY – WE LOOK FORWARD TO MEETING YOU IN ITALY IN 2021!

 

We would like to invite you to the beautiful ancient city where antiquity meets modernity – Rome! The city where science has grown now will hold the most significant and the biggest conference on Raman Spectroscopy – ICORS20/21. We would like to proudly announce that we are official sponsors of this conference among such gigantic companies as HORIBA, WITec, or Edinburgh Instruments.

Make sure you take a vacation before or after the conference to visit the city. We recommend it from our own experience! You will find an ancient building, beautiful sculptures, and more on every step you make!

Keywords: SERS, Raman, Non-linear and time resolved Sers, Ters and plasmonics, Material science, Fundamentals and theory, Biology and biomedicine, Novel Techniques, analytics and applications, photoscience in biology, experimental techniques, Raman spectroscopy, theoretical approaches, single molecules, synthesis methods, ultrafast photochemistry, photoscience at nanoscale, infrared spectroscopy, surface enhanced raman spectroscopy, conference, ICORS20/21
Virtual Raman Imaging Poster Summit 2020

We are going to participate in WITec Poster Summit that will start on Monday, Sep. 28th at 14:00 (CEST) and run until Friday, Oct. 2nd at 12:00 (CEST).

If you want to see our new features, see our poster or ask questions you must be there with us!

Keywords: photoscience in biology, experimental techniques, fluorescence microscopy, Raman spectroscopy, theoretical approaches, single molecules, synthesis methods, ultrafast photochemistry, photoscience at nanoscale, infrared spectroscopy, SERS, surface enhanced raman spectroscopy, COVID19, WITec, Poster, Virtual Raman Poster Summit
Fabrication of nanocages on nickel using femtosecond laser ablation and trace level detection of malachite green and Nile blue dyes using surface enhanced Raman spectroscopic technique (November, 2020)

BYRAM CHANDU, MORAM SREE SATYA BHARATI, PAWEŁ ALBRYCHT, SOMA VENUGOPAL RAO

Over the last decade several research groups have accomplished the fabrication of 2D periodic and 3D nanocage like structures on different materials using diverse lithographic approaches. Herein, we present the detailed studies on the fabrication of femtosecond (fs) laser‐induced periodic/ripple‐like surface structures on nickel (Ni) substrate in distilled water whereas 3D-like (nanocages) features on Ni substrates in acetone by tailoring the laser processing parameters (pulse energy). The morphological studies of simultaneously obtained Ni nanoparticles (NPs)/nanostructures (NSs) in distilled water/acetone were meticulously studied using transmission electron microscope (TEM) and field emission scanning electron microscope (FESEM). The fabricated Ni periodic/3D-like structures were gold (Au) plated using thermal evaporation technique and subsequently utilized as surface enhanced Raman scattering (SERS) active sensors for detecting the traces of various analyte molecules such as malachite green (MG) and Nile blue (NB). The grooved Ni-Au substrates allowed us to detect extremely low concentrations of MG (500 pM) and NB (5 nM) and, significantly, utilizing a simple, portable Raman spectrometer. Moreover, the substrates have demonstrated superior reproducibility as well as multi-utility nature with a relative standard deviation (RSD) of <17%. Additionally, Au- coated Ni grooved SERS substrates have demonstrated superior sensitivity and reproducibility in comparison to commercially available Ag-based SERS sensors (SERSitive, Poland). The proposed method of fabricating ripple and nanocages of Ni SERS platforms are highly viable to overcome the cost and one-time usage of substrates for on-site detection of several analyte molecules using a portable/hand-held Raman spectrometer.

Keywords: Keywords: Laser Induced Periodic Surface Structures (LIPSS), Malachite green, Nanocages, Nickel Nanostructure (NS), Nile blue, SERS, Substrates, Surface scattering, Laser ablation, Raman, Relative standard deviations
Fast and efficient deposition of broad range of analytes on substrates for surface enhanced Raman spectroscopy

ŁUKASZ RICHTER, PAWEŁ ALBRYCHT, MONIKA KSIĘŻOPOLSKA-GOCALSKA, EWA POBOŻY, ROBERT BACHLIŃSKIC, VOLODYMYR SASHUK, JAN PACZESNY, ROBERT HOŁYST

The majority of analytical chemistry methods requires presence of target molecules directly at a sensing surface. Diffusion of analyte from the bulk towards the sensing layer is random and might be extremely lengthy, especially in case of low concentration of molecules to be detected. Thus, even the most sensitive transducer and the most selective sensing layer are limited by the efficiency of deposition of molecules on sensing surfaces. However, rapid development of new sensing technologies is rarely accompanied by new protocols for analyte deposition. To bridge this gap, we propose a method for fast and efficient deposition of variety of molecules (e.g. proteins, dyes, drugs, biomarkers, amino acids) based on application of the alternating electric field. We show the dependence between frequency of the applied electric field, the intensity of the surface enhanced Raman spectroscopy (SERS) signal and the mobility of the studied analyte. Such correlation allows for a priori selection of parameters for any desired compound without additional optimization. Thanks to the application of the electric field, we improve SERS technique by decrease of time of deposition from 20 h to 5 min, and, at the same time, reduction of the required sample volume from 2 ml to 50 μl. Our method might be paired with number of analytical methods, as it allows for deposition of molecules on any conductive surface, or a conductive surface covered with dielectric layer.

Keywords: Deposition, Electric field, Surface-enhanced Raman spectroscopy, SERS, Analyte, Detection
SERSitive is an official sponsor of 10th International Conference on Advanced Vibrational Spectroscopy ICACS10

We are proud to announce that SERSitive is a sponsor of 10th International Conference on Advanced Vibrational Spectroscopy ICACS10 that will be held at the University of Auckland in the centre of Auckland city, New Zeland, 7-12 July 2019.

Read more about ICAVS http://www.icavs.org/2019-conference/

Keywords: photoscience in biology, experimental techniques, fluorescence microscopy, Raman spectroscopy, theoretical approaches, single molecules, synthesis methods, ultrafast photochemistry, photoscience at nanoscale, infrared spectroscopy, SERS, surface enhanced raman spectroscopy. conference, sponsorship, sponsor, official sponsor, ICAVS10, Auckland, New Zeland
SERSitive was awarded a platinum medal

SERSitive was awarded a platinum medal for invention:
“A method of depositing metal nanoparticles on a surface in an electrochemical process, the surface obtained by this method and its application”
during the International Warsaw Invention Show 2018 (15-17.10.2018).

Authored by: Monika Księżopolska-Gocalska, Paweł Albrycht, Ewa Roźniecka, Joanna Niedziółka-Jӧnsson, Marta Podrażka, Robert Hołyst

Keywords: experimental techniques, Raman spectroscopy, theoretical approaches, single molecules, synthesis methods, ultrafast photochemistry, photoscience at nanoscale, SERS, surface enhanced raman spectroscopy, invention, invention show, platinum medal, award, warsaw invention show
SERSitive: New substrates make it possible to routinely detect one molecule in a million

We are happy to announce that there is a press note about our research and company available

SERS, an extremely sensitive laboratory method of analysing chemical composition, is set to become widespread decades after its invention. The main obstacle that has been slowing down the development of this promising research technique, the poor quality of the substrate on which samples are applied, is now disappearing. New substrates, guaranteeing repeatability of measurements and the appropriate signal enhancement, are now available thanks to scientists from the Institute of Physical Chemistry of the Polish Academy of Sciences in Warsaw…

Keywords: SERS, Raman, photoscience in biology, experimental techniques, Raman spectroscopy, theoretical approaches, single molecules, synthesis methods, ultrafast photochemistry, photoscience at nanoscale, infrared spectroscopy, surface enhanced raman spectroscopy, press, sciene, big scale research,