Development of a commercial method to produce SERS substrates for ultra-sensitive and quick biomedical analysis.
Development of a commercial method to produce SERS substrates for ultra-sensitive and quick biomedical analysis.
We have a piece of great news for all our (current and future) customers from the USA and Mexico:
SERSitive has just started the first business cooperation based on distribution with Amerigo Scientific from the life science industry!
From now on, Amerigo Scientific (https://www.amerigoscientific.com/) is our official Distributor in the USA and Mexico!
Do not hesitate to contact Amerigo and order our products!
We are convinced that our cooperation will be fruitful and developmental 🙂
This online conference focuses on medical life sciences intending to promote Baltic photonics and laser technologies, life science and medical research and innovations.
We will present our SERS-based solutions and the potential of combining them with Artificial Intelligence, which might be a brand new way for medical diagnosis of pathogens and life sciences research.
Event page: https://toolas.eu/baltic-photonics-2021-medlife/
Registration is free of charge: https://forms.gle/pm2xhpnssRK4Z6Xp7
(all registered participants will receive a link to translation platform, where they can as questions to the speakers in the chat)
Join us on September 16, 2021 🙂
Jamelah S. Al-Otaibi, Paweł Albrycht, Y. Sheena Mary, Y. Shyma Mary & Monika Księżopolska-Gocalska
Using nanosized metal substrates, surface-enhanced Raman scattering (SERS) is a tool for improving the Raman signal of biomolecules. For detection, SERS has gained much popularity and an important role in determining chemical composition. In the present study, SERS spectra of 2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine (olanzapine) (MPTB) were investigated on silver and silver-gold metal substrates (SERSitive, Warsaw, Poland) at different concentrations. Also, different chemical and electronic properties are investigated using DFT calculations. The ring and other functional modes in SERS change in frequency values with variations in intensity for all concentrations. The molecule is oriented in a tilted manner with respect to Ag and Ag-Au.
Paweł Albrycht, Jamelah S. Al-Otaibi, Y. Sheena Mary, Y. Shyma Mary, Ravi Trivedi, Brahmananda Chakraborty
Surface enhanced Raman scattering (SERS) is a spectroscopic technique for trace analysis where the efficiency depends on the substrate. In the present work, concentration-dependent SERS of pioglitazone (EPMT) in silver and silver-gold substrates are reported. The presence and absence of different SERS peaks between the analyte spectra on silver and silver-gold substrates show that there is an orientation change of the analyte adsorbed depending on the surface-active metal. The density functional theory (DFT) method was used to verify the experimental findings obtained from normal Raman and SERS spectra. Theoretical modeling of EPMT and metal clusters are reported and enhancement factors are found from theoretical and experimental results. In the EPMT-Ag-Ag and EPMT-Ag-Au molecular systems, Frontier molecular orbital’s (FMO’s) results highlight charge transfers from Ag-Ag/Ag-Au clusters to the molecule. Furthermore, the SERS enhancement factor values show that EPMT is chemisorbed.
We are so excited! Our ideas for developing SERSitive SERS substrates for biomedicine applications were appreciated by the PARP and NCBiR for the most innovative Polish products and technologies in the competition for the Polish Product of the Future!
We were honoured with two awards:
1) Distinction Award in the category “Modern Science Solutions”
2) Special Award of the Ministry of Education and Science
We are very thankful that we could participate in this prestigious competition and could share our #innovativesolutions 😊
MOCCI F, OLLA C, CAPPAI A, CORPINO R, RICCI PC, CHIRIU D, SALIS M, CARBONARO CM.
The molecular model is one of the most appealing to explain the peculiar optical properties of Carbon nanodots (CNDs) and was proven to be successful for the bottom up synthesis, where a few molecules were recognized. Among the others, citrazinic acid is relevant for the synthesis of citric acid-based CNDs. Here we report a combined experimental and computational approach to discuss the formation of different protonated and deprotonated species of citrazinic acid and their contribution to vibrational and magnetic spectra. By computing the free energy formation in water solution, we selected the most favoured species and we retrieved their presence in the experimental surface enhanced Raman spectra. As well, the chemical shifts are discussed in terms of tautomers and rotamers of most favoured species. The expected formation of protonated and de-protonated citrazinic acid ions under extreme pH conditions was proven by evaluating specific interactions with H2SO4 and NaOH molecules. The reported results confirm that the presence of citrazinic acid and its ionic forms should be considered in the interpretation of the spectroscopic features of CNDs.
Antonio Cappai, Claudio Melis, Luigi Stagi, Pier C. Ricci, Francesca Mocci, and Carlo M. Carbonaro
The molecular emission model is the most accredited one to explain the emission properties of carbon dots (CDs) in a low-temperature bottom-up synthesis approach. In the case of citric acid and urea, the formation of a citrazinic acid (CZA) single monomer and oligomers is expected to affect the optical properties of the CDs. It is therefore mandatory to elucidate the possible role of weak bonding interactions in determining the UV absorption spectrum of some molecular aggregates of CZA. Although this carboxylic acid is largely exploited in the synthesis of luminescent CDs, a full understanding of its role in determining the final emission spectra of the produced CDs is still very far to be achieved. To this aim, by relying on purely first-principles density functional theory calculations combined with experimental optical characterization, we built and checked the stability of some molecular aggregates, which could possibly arise from the formation of oligomers of CZA, mainly dimers, trimers, and some selected tetramers. The computed vibrational fingerprint of the formation of aggregates is confirmed by surface-enhanced Raman spectroscopy. The comparison of experimental data with calculated UV absorption spectra showed a clear impact of the final morphology of the aggregates on the position of the main peaks in the UV spectra, with particular regard to the 340 nm peak associated with n-π* transition.
17-18 Februbary 2021, International Online Conference- WE LOOK FORWARD TO MEETING YOU There!
The two-day Small Chem 2021 Online International Conference will present the most recent advances in fundamental research, technology developments and business opportunities in the Chemistry sector. More than 25 high profile talks from worldwide most influential academia & industry experts will present speeches in this international event on how chemistry latest advances will impact positively our daily life.
Small Chem 2021 will be a two-day online event that means to gather the key players of the Chemistry community and related sectors. This event is launched considering that all major scientific and technological in-person conferences are being cancelled or postponed worldwide until middle of 2021.
We would like to invite you and your community to an event like never before, where it is not your skills but your groundbreaking dreams that count!
Welcome to international competition for young scientists:
Dream Chemistry Award 2020
with the special event:
“Perspectives on the chemistry publishing landscape.”
Lecture delivered by Russell Johnson editor at Nature Chemistry
1st of December 2020, 06:00 p.m. – 09:00 p.m. CET
Lecture of the winner of the DCA 2020
“Perspectives on the chemistry publishing landscape“
Lecture delivered by Russel Johnson editor at Nature Chemistry
YouTube online stream of DCA 2020 – Day 2
1-6 AUGUST 2021, ROME, ITALY – WE LOOK FORWARD TO MEETING YOU IN ITALY IN 2021!
We would like to invite you to the beautiful ancient city where antiquity meets modernity – Rome! The city where science has grown now will hold the most significant and the biggest conference on Raman Spectroscopy – ICORS20/21. We would like to proudly announce that we are official sponsors of this conference among such gigantic companies as HORIBA, WITec, or Edinburgh Instruments.
Make sure you take a vacation before or after the conference to visit the city. We recommend it from our own experience! You will find an ancient building, beautiful sculptures, and more on every step you make!
We are going to participate in WITec Poster Summit that will start on Monday, Sep. 28th at 14:00 (CEST) and run until Friday, Oct. 2nd at 12:00 (CEST).
If you want to see our new features, see our poster or ask questions you must be there with us!
BYRAM CHANDU, MORAM SREE SATYA BHARATI, PAWEŁ ALBRYCHT, SOMA VENUGOPAL RAO
Over the last decade several research groups have accomplished the fabrication of 2D periodic and 3D nanocage like structures on different materials using diverse lithographic approaches. Herein, we present the detailed studies on the fabrication of femtosecond (fs) laser‐induced periodic/ripple‐like surface structures on nickel (Ni) substrate in distilled water whereas 3D-like (nanocages) features on Ni substrates in acetone by tailoring the laser processing parameters (pulse energy). The morphological studies of simultaneously obtained Ni nanoparticles (NPs)/nanostructures (NSs) in distilled water/acetone were meticulously studied using transmission electron microscope (TEM) and field emission scanning electron microscope (FESEM). The fabricated Ni periodic/3D-like structures were gold (Au) plated using thermal evaporation technique and subsequently utilized as surface enhanced Raman scattering (SERS) active sensors for detecting the traces of various analyte molecules such as malachite green (MG) and Nile blue (NB). The grooved Ni-Au substrates allowed us to detect extremely low concentrations of MG (500 pM) and NB (5 nM) and, significantly, utilizing a simple, portable Raman spectrometer. Moreover, the substrates have demonstrated superior reproducibility as well as multi-utility nature with a relative standard deviation (RSD) of <17%. Additionally, Au- coated Ni grooved SERS substrates have demonstrated superior sensitivity and reproducibility in comparison to commercially available Ag-based SERS sensors (SERSitive, Poland). The proposed method of fabricating ripple and nanocages of Ni SERS platforms are highly viable to overcome the cost and one-time usage of substrates for on-site detection of several analyte molecules using a portable/hand-held Raman spectrometer.
ŁUKASZ RICHTER, PAWEŁ ALBRYCHT, MONIKA KSIĘŻOPOLSKA-GOCALSKA, EWA POBOŻY, ROBERT BACHLIŃSKIC, VOLODYMYR SASHUK, JAN PACZESNY, ROBERT HOŁYST
The majority of analytical chemistry methods requires presence of target molecules directly at a sensing surface. Diffusion of analyte from the bulk towards the sensing layer is random and might be extremely lengthy, especially in case of low concentration of molecules to be detected. Thus, even the most sensitive transducer and the most selective sensing layer are limited by the efficiency of deposition of molecules on sensing surfaces. However, rapid development of new sensing technologies is rarely accompanied by new protocols for analyte deposition. To bridge this gap, we propose a method for fast and efficient deposition of variety of molecules (e.g. proteins, dyes, drugs, biomarkers, amino acids) based on application of the alternating electric field. We show the dependence between frequency of the applied electric field, the intensity of the surface enhanced Raman spectroscopy (SERS) signal and the mobility of the studied analyte. Such correlation allows for a priori selection of parameters for any desired compound without additional optimization. Thanks to the application of the electric field, we improve SERS technique by decrease of time of deposition from 20 h to 5 min, and, at the same time, reduction of the required sample volume from 2 ml to 50 μl. Our method might be paired with number of analytical methods, as it allows for deposition of molecules on any conductive surface, or a conductive surface covered with dielectric layer.
We are proud to announce that SERSitive is a sponsor of 10th International Conference on Advanced Vibrational Spectroscopy ICACS10 that will be held at the University of Auckland in the centre of Auckland city, New Zeland, 7-12 July 2019.
Read more about ICAVS http://www.icavs.org/2019-conference/